Article
Novel genetic approach to investigate the role of plasma secretory phospholipase A2 (sPLA2)-V isoenzyme in coronary heart disease: modified Mendelian randomization analysis using PLA2G5 expression levels.
Circulation. Cardiovascular genetics - 1 Apr 2014
Holmes Michael V, Exeter Holly J, Folkersen Lasse, Nelson Christopher P, Guardiola Montse, Cooper Jackie A, Sofat Reecha, Boekholdt S Matthijs, Khaw Kay-Tee, Li Ka-Wah, Smith Andrew J P, Van't Hooft Ferdinand, Eriksson Per, Franco-Cereceda Anders, Asselbergs Folkert W, Boer Jolanda M A, Onland-Moret N Charlotte, Hofker Marten, Erdmann Jeanette, Kivimaki Mika, Kumari Meena, Reiner Alex P, Keating Brendan J, Humphries Steve E, Hingorani Aroon D, Mallat Ziad, Samani Nilesh J, Talmud Philippa J
Abstract excerpt
BACKGROUND: Secretory phospholipase A2 (sPLA2) enzymes are considered to play a role in atherosclerosis. sPLA2 activity encompasses several sPLA2 isoenzymes, including sPLA2-V. Although observational studies show a strong association between elevated sPLA2 activity and CHD, no assay to measure sP...
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