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Article

The APC tumor suppressor is required for epithelial integrity in the mouse mammary gland.

Journal of cellular physiology - 1 Aug 2009

Prosperi Jenifer R, Becher Kimberly R, Willson Tara A, Collins Margaret H, Witte David P, Goss Kathleen H

Abstract excerpt

Inactivation of the adenomatous polyposis coli (APC) tumor suppressor has been associated with mammary tumorigenesis in mouse models and through epidemiological studies of human breast cancers, but the normal role for APC in mammary development has not been thoroughly characterized. We report here that Apc(Min/+) mice containing one functional allele of Apc have severely disrupted lobuloalveolar development...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19326388
DOI: 10.1002/jcp.21766

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The APC tumor suppressor is required for epithelial integrity in the mouse mammary gland.PMID 19326388Read ↗

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