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Article

Foxo1 mediates insulin action on apoC-III and triglyceride metabolism.

The Journal of clinical investigation - 1 Nov 2004

Altomonte Jennifer, Cong Lin, Harbaran Sonal, Richter Anja, Xu Jing, Meseck Marcia, Dong Hengjiang Henry

Abstract excerpt

The apolipoprotein apoC-III plays an important role in plasma triglyceride metabolism. It is predominantly produced in liver, and its hepatic expression is inhibited by insulin. To elucidate the inhibitory mechanism of insulin in apoC-III expression, we delivered forkhead box O1 (Foxo1) cDNA to hepatocytes by adenovirus-mediated gene transfer. Foxo1 stimulated hepatic apoC-III expression and correlated with the...

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Identifiers

PMID: 15546000
DOI: 10.1172/JCI19992
PMCID: PMC525736

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Foxo1 mediates insulin action on apoC-III and triglyceride metabolism.PMID 15546000Read ↗

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