Article
The forkhead transcription factor Foxo1 regulates adipocyte differentiation.
Developmental cell - 1 Jan 2003
Nakae Jun, Kitamura Tadahiro, Kitamura Yukari, Biggs William H, Arden Karen C, Accili Domenico
Abstract excerpt
An outstanding question in adipocyte biology is how hormonal cues are relayed to the nucleus to activate the transcriptional program that promotes adipogenesis. The forkhead transcription factor Foxo1 is regulated by insulin via Akt-dependent phosphorylation and nuclear exclusion. We show that Fo...
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