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Article

A coding single-nucleotide polymorphism in lysine demethylase KDM4A associates with increased sensitivity to mTOR inhibitors.

Cancer discovery - 1 Mar 2015

Van Rechem Capucine, Black Joshua C, Greninger Patricia, Zhao Yang, Donado Carlos, Burrowes Paul D, Ladd Brendon, Christiani David C, Benes Cyril H, Whetstine Johnathan R

Abstract excerpt

UNLABELLED: SNPs occur within chromatin-modulating factors; however, little is known about how these variants within the coding sequence affect cancer progression or treatment. Therefore, there is a need to establish their biochemical and/or molecular contribution, their use in subclassifying patients, and their impact on therapeutic response. In this report, we demonstrate that coding SNP-A482 within the lysine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25564517
DOI: 10.1158/2159-8290.CD-14-1159
PMCID: PMC4355226

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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