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Article

Natural variation in the histone demethylase, KDM4C, influences expression levels of specific genes including those that affect cell growth.

Genome research - 1 Jan 2014

Gregory Brittany L, Cheung Vivian G

Abstract excerpt

DNA sequence variants influence gene expression and cellular phenotypes. In this study, we focused on natural variation in the gene encoding the histone demethylase, KDM4C, which promotes transcriptional activation by removing the repressive histone mark, H3K9me3, from its target genes. We uncovered cis-acting variants that contribute to extensive individual differences in KDM4C expression. We also identified the...

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Share to Epigenesis, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Jumonji Domain-Containing Histone Demethylases

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Identifiers

PMID: 24285722
DOI: 10.1101/gr.156141.113
PMCID: PMC3875861

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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