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Article

Functional evaluation of missense variations in the human MAD1L1 and MAD2L1 genes and their impact on susceptibility to lung cancer.

Journal of medical genetics - 1 Sept 2010

Guo Yongli, Zhang Xuemei, Yang Ming, Miao Xiaoping, Shi Yuankai, Yao Jiarui, Tan Wen, Sun Tong, Zhao Dan, Yu Dianke, Liu Junniao, Lin Dongxin

Abstract excerpt

BACKGROUND: Human MAD1 mitotic arrest deficient-like 1 (MAD1L1) and MAD2 mitotic arrest deficient-like 1 (MAD2L1) are two interactive proteins playing important roles in maintaining spindle checkpoint function. This study examined the functional relevance of missense coding single nucleotide polymorphisms (SNPs) in MAD1L1 and MAD2L1 and their association with susceptibility to lung cancer. METHODS: SNPs in the...

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PMID: 20516147
DOI: 10.1136/jmg.2009.074252

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