Article

Differences in substrate engagement and Retinoblastoma protein (RB) binding of human KDM5A and KDM5B

2026-05-02

Abstract excerpt

Trimethylation of lysine 4 of histone H3 (H3K4me3) is a post-translational modification (PTM) enriched at promoters of actively transcribed genes. H3K4me3 is removed by the human histone demethylases of the KDM5 family. KDM5 demethylases act as transcriptional repressors through their catalytic activity in addition to more complex roles that depend on their interactions with other chromatin regulators and may be i...

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Literature Corpus work: 9e37d9c7-5bd7-53e5-b40e-5d5709203426
DOI: 10.64898/2026.04.30.721888

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