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Histone methyltransferase KMT5C drives liver cancer progression and directs therapeutic response to PARP inhibitors

9 Aug 2023

Abstract excerpt

BACKGROUND AND AIMS: Epigenetic plasticity is a major challenge in cancer-targeted therapy. However, the molecular basis governing this process has not yet been clearly defined. Despite the considerable success of poly(ADP-ribose) polymerase inhibitors (PARPi) in cancer therapy, the limited response to PARPi, especially in HCC, has been a bottleneck in its clinical implications. Herein, we investigated the...

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PMID: 37556368
DOI: 10.1097/hep.0000000000000559

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