Article
Somatic mutations of MLL4/COMPASS induce cytoplasmic localization providing molecular insight into cancer prognosis and treatment.
Proceedings of the National Academy of Sciences of the United States of America - 26 Dec 2023
Zhao Zibo, Aoi Yuki, Philips Cassandra N, Meghani Khyati A, Gold Sarah R, Yu Yanni, John Luke St, Qian Jun, Zeidner Jacob M, Meeks Joshua J, Shilatifard Ali
Abstract excerpt
Cancer genome sequencing consortiums have recently catalogued an abundance of somatic mutations, across a wide range of human cancers, in the chromatin-modifying enzymes that regulate gene expression. Defining the molecular mechanisms underlying the potentially oncogenic functions of these epigenetic mutations could serve as the basis for precision medicine approaches to cancer therapy. MLL4 encoded by the KMT2D...
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