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The lysine demethylase, KDM4B, is a key molecule in androgen receptor signalling and turnover

21 Feb 2013

Abstract excerpt

The androgen receptor (AR) is a key molecule involved in prostate cancer (PC) development and progression. Post-translational modification of the AR by co-regulator proteins can modulate its transcriptional activity. To identify which demethylases might be involved in AR regulation, an siRNA screen was performed to reveal that the demethylase, KDM4B, may be an important co-regulator protein. KDM4B enzymatic...

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PMID: 23435229
DOI: 10.1093/nar/gkt106

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