Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rare KDM4C variants and reduced expression underlie epigenetic dysregulation in rheumatoid arthritis.

Immunologic research - 13 Feb 2026

Oner Deniz Aslar, Toktas Hasan, Dundar Umit, Adar Sevda, Eyvaz Nuran

Abstract excerpt

This study aims to investigate structural and expression-level alterations in the histone demethylase KDM4C gene in patients with rheumatoid arthritis (RA) and elucidate its role in the disease's epigenetic basis. KDM4C sequencing was performed in RA patients, and identified variants were mapped to functional domains, including the JmjN and PHD-type2 regions. KDM4C expression was assessed by quantitative PCR in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arthritis, Rheumatoid
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CRP gene

Share to Gene Expression Regulation

Share to Genetic Predisposition to Disease

Share to Histones

Share to Jumonji Domain-Containing Histone Demethylases

Share to Mutation, Missense

Source

Open in PubMed Open full text

Identifiers

PMID: 41680357
DOI: 10.1007/s12026-026-09751-9
PMCID: PMC12901242

Genes

KDM4C
CRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rare KDM4C variants and reduced expression underlie epigenetic dysregulation in rheumatoid arthritis.PMID 41680357Read ↗

JMJD family proteins in cancer and inflammationSemantic proximity Read ↗

From histones to ribosomes: a chromatin regulator tangoes with translation.Semantic proximity Read ↗

Natural variation in the histone demethylase, KDM4C, influences expression levels of specific genes including those that affect cell growth.Semantic proximity Read ↗

Mutations in the intellectual disability gene KDM5C reduce protein stability and demethylase activity.Semantic proximity Read ↗

Novel germline variant in the histone demethylase and transcription regulator KDM4C induces a multi-cancer phenotype.Semantic proximity Read ↗

A coding single-nucleotide polymorphism in lysine demethylase KDM4A associates with increased sensitivity to mTOR inhibitors.Semantic proximity Read ↗

Hypomethylation of the <em>Dual Specificity Phosphatase</em> (<em>DUSP22</em>) Promoter in Cell-Free DNA (cf-DNA) Is Associated with Rheumatoid Arthritis and Joint Space NarrowingSemantic proximity Read ↗

The KDM4B–CCAR1–MED1 axis is a critical regulator of osteoclast differentiation and bone homeostasisSemantic proximity Read ↗

DNA methylation change of HIPK3 in Chinese rheumatoid arthritis and its effect on inflammationSemantic proximity Read ↗

Rheumatoid arthritis-associated RBPJ polymorphism alters memory CD4+ T cells.Semantic proximity Read ↗

Cofactors-loaded quaternary structure of lysine-specific demethylase 5C (KDM5C) protein: Computational model.Semantic proximity Read ↗

Mutations in JMJD1C are involved in Rett syndrome and intellectual disability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.