Influence of the KDM4A rs586339 polymorphism on overall survival in Asian non-small-cell lung cancer patients.

doi:10.1097/FPC.0000000000000266

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Influence of the KDM4A rs586339 polymorphism on overall survival in Asian non-small-cell lung cancer patients.

Pharmacogenetics and genomics - 1 Mar 2017

Marvalim Charlie, Wong Jing Xiang Gimson, Sutiman Natalia, Lim Wan Teck, Tan Shao Weng, Kanesvaran Ravindran, Ng Quan Sing, Jain Amit, Ang Mei Kim, Tan Wan Ling, Toh Chee Keong, Tan Eng Huat, Chowbay Balram

Abstract excerpt

The critical role of lysine demethylase 4A (KDM4A), in regulating chromatin structure and consequently in driving cellular proliferation and oncogenesis has been the focus of recent studies. Non-small-cell lung cancer (NSCLC) patients with adenocarcinoma histology who were homozygous for KDM4A single nucleotide polymorphism (SNP)-A482 (rs586339) were recently shown to have significantly worse overall survival...

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PMID: 28059867
DOI: 10.1097/FPC.0000000000000266

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