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Article

Genetic transmission of cytochrome P450 2D6 (CYP2D6) ultrarapid metabolism: implications for breastfeeding women taking codeine.

Current drug safety - 1 Feb 2011

Madadi Parvaz, Ciszkowski Catherine, Gaedigk Andrea, Leeder J Steven, Teitelbaum Ronni, Chitayat David, Koren Gideon

Abstract excerpt

The pro-drug codeine is commonly prescribed for postpartum pain relief in North America. The safety of codeine during breastfeeding is related in part to the extent of the active morphine metabolite catalyzed from codeine via the cytochrome P450 2D6 (CYP2D6) enzyme. In mothers who have greater than two functional copies of the CYP2D6 gene (CYP2D6 ultrarapid metabolism phenotype; UM) a substantially higher...

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Identifiers

PMID: 21241245
DOI: 10.2174/157488611794479991

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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