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Article

Analysis Approaches to Identify Pharmacogenetic Associations With Pharmacodynamics.

Clinical pharmacology and therapeutics - 1 Sept 2021

Hertz Daniel L, Ramsey Laura B, Gopalakrishnan Mathangi, Leeder J Steven, Van Driest Sara L

Abstract excerpt

Pharmacogenetics (PGx) seeks to enable selection of the right dose of the right drug for each patient to optimize therapeutic outcomes. Most PGx focuses on pharmacokinetics (PKs), due to our relatively advanced understanding of the genes involved in PKs and the causative effects of variants in those genes. Genetic variants can also affect pharmacodynamics (PDs), but relatively few PGx-PD associations have been...

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Identifiers

PMID: 34043820
DOI: 10.1002/cpt.2312
PMCID: PMC10947489

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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