Article

Dampened PI3K/AKT signaling contributes to cancer resistance of the naked mole rat

2020-02-28

Abstract excerpt

Mammalian species have a dramatically different susceptibility to cancer. However, how cancer-resistant species resist oncogenic transformation is not fully understood. Here, we performed a comprehensive analysis of oncogene-induced transcriptional changes in the fibroblasts of a cancer-prone species, the mouse, and three cancer-resistant species, the human, the blind mole rat, and the naked mole rat. We report th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0cdfa4d2-8b52-550d-ac92-5414299fada7
DOI: 10.1101/2020.02.27.967729

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dampened PI3K/AKT signaling contributes to cancer resistance of the naked mole ratDOI 10.1101/2020.02.27.967729Read

Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-ratSemantic proximity Read

Mechanisms of cancer resistance in long-lived mammals.Semantic proximity Read

Naked Mole-Rat Cells are Susceptible to Malignant Transformation by <i>SV40LT</i> and Oncogenic RasSemantic proximity Read

Mouse tissues that undergo neoplastic progression after K-Ras activation are distinguished by nuclear translocation of phospho-Erk1/2 and robust tumor suppressor responses.Semantic proximity Read

An autochthonous model of lung cancer in the Naked Mole-Rat ( <i>Heterocephalus glaber</i> )Semantic proximity Read

Accelerated pathway evolution in mouse-like rodents involves cell cycle control.Semantic proximity Read

Resistance to chemical carcinogenesis induction via a dampened inflammatory response in naked mole-ratsSemantic proximity Read

Regenerative cell turnover coupled to a tumor-hostile niche protects naked mole-rats from cancerSemantic proximity Read

Partners in crime: the TGFβ and MAPK pathways in cancer progressionSemantic proximity Read

Cancerous perturbations within the ERK, PI3K/Akt, and Wnt/β-catenin signaling network constitutively activate inter-pathway positive feedback loops.Semantic proximity Read

Conserved Pathways, Divergent Outcomes: A Cross-Species Genomic Perspective on the Cancer–Neurodegeneration ParadoxSemantic proximity Read

Global expression profiling and pathway analysis of mouse mammary tumor reveals strain and stage specific dysregulated pathways in breast cancer progression.Semantic proximity Read