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Article

Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat

26 Oct 2009

Abstract excerpt

The naked mole-rat is the longest living rodent with a maximum lifespan exceeding 28 years. In addition to its longevity, naked mole-rats have an extraordinary resistance to cancer as tumors have never been observed in these rodents. Furthermore, we show that a combination of activated Ras and SV40 LT fails to induce robust anchorage-independent growth in naked mole-rat cells, while it readily transforms mouse...

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PMID: 19858485
DOI: 10.1073/pnas.0905252106

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