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Article

The meaning of p16<sup>ink4a</sup>expression in tumors

1 Aug 2011

Abstract excerpt

The CDKN2A gene is a tumor suppressor that encodes the CDK4/6 inhibitor p16(ink4a). Loss of this tumor suppressor contributes to the bypass of critical senescent signals and is associated with progression to malignant disease. However, the high-level expression of p16(ink4a) in tumors is associated with aggressive subtypes of disease, and in certain clinical settings elevated p16(ink4a) expression is an important...

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PMID: 21775818
DOI: 10.4161/cc.10.15.16776

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