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Article

Effector T cells boost regulatory T cell expansion by IL-2, TNF, OX40, and plasmacytoid dendritic cells depending on the immune context.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2015

Baeyens Audrey, Saadoun David, Billiard Fabienne, Rouers Angéline, Grégoire Sylvie, Zaragoza Bruno, Grinberg-Bleyer Yenkel, Marodon Gilles, Piaggio Eliane, Salomon Benoît L

Abstract excerpt

CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cells play a major role in peripheral tolerance. Multiple environmental factors and cell types affect their biology. Among them, activated effector CD4(+) T cells can boost Treg cell expansion through TNF or IL-2. In this study, we further characterized t...

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Identifiers

PMID: 25548233
DOI: 10.4049/jimmunol.1400504

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25548233-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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