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Article

Enhanced renewal of regulatory T cells in relation to CD4(+) conventional T lymphocytes in the peripheral compartment.

Immunology - 1 Feb 2016

Nogueira Jeane de Souza, Canto Fábio Barrozo do, Nunes Caroline Fraga Cabral Gomes, Vianna Pedro Henrique Oliveira, Paiva Luciana de Souza, Nóbrega Alberto, Bellio Maria, Fucs Rita

Abstract excerpt

CD4(+) Foxp3(+) regulatory T (Treg) cells are necessary for the maintenance of self-tolerance and T-cell homeostasis. This population is kept at stable frequencies in secondary lymphoid organs for the majority of the lifetime, despite permanent thymic emigration or in the face of thymic involution. Continuous competition is expected to occur between recently thymus-emigrated and resident Treg cells (either...

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Identifiers

PMID: 26572097
DOI: 10.1111/imm.12555
PMCID: PMC4717236

Genes

RAG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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