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Article

Dendritic cells control CD4+CD25+ Treg cell suppressor function in vitro through juxtacrine delivery of IL-2.

PloS one - 1 Jan 2012

Kulhankova Katarina, Rouse Todd, Nasr Mohamed E, Field Elizabeth H

Abstract excerpt

CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs) restrict inflammatory responses to self and nonself. Aberrant Treg activity is pathologic: Insufficient Treg activity is implicated in autoimmunity, allergy, and graft-versus-host-disease; overabundant activity is implicated in chronic infection and cancer. Tregs require IL-2 for their expansion and acquisition/execution of suppressor function; however, because...

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PMID: 22984435
DOI: 10.1371/journal.pone.0043609
PMCID: PMC3440416

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