Article
Ex vivo expansion of CD4+CD25+FoxP3+ T regulatory cells based on synergy between IL-2 and 4-1BB signaling.
Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2007
Elpek Kutlu G, Yolcu Esma S, Franke Deanna D H, Lacelle Chantale, Schabowsky Rich-Henry, Shirwan Haval
Abstract excerpt
Naturally occurring CD4(+)CD25(+)FoxP3(+) T regulatory (Treg) cells require three distinct signals transduced via TCR, CD28, and IL-2R for their development and maintenance. These requirements served as the basis for several recently developed ex vivo expansion protocols that relied on the use of solid support-bound Abs to CD3 and CD28 in the presence of high dose IL-2. We report in this study that Treg cells...
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