Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Excess generation and activation of naturally arising memory-phenotype CD4+ T lymphocytes are inhibited by regulatory T cells in steady state.

Frontiers in immunology - 1 Jan 2024

Li Jing, Yang Ziying, Kawajiri Akihisa, Sato Kosuke, Tayama Shunichi, Ishii Naoto, Zhu Jinfang, Kawabe Takeshi

Abstract excerpt

Conventional CD4+ T lymphocytes consist of naïve, foreign antigen-specific memory, and self-antigen-driven memory-phenotype (MP) cell compartments at homeostasis. We recently showed that MP cells tonically proliferate in response to self-antigens and differentiate into the T-bet+ subset in steady state. How excess proliferation and differentiation of MP cells are inhibited remains unclear. Given immunosuppressive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD4-Positive T-Lymphocytes
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Proliferation

Share to Immunologic Memory

Share to Lymphocyte Activation

Share to Mice, Transgenic

Share to T-Lymphocytes, Regulatory

Share to Th1 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 39221254
DOI: 10.3389/fimmu.2024.1429954
PMCID: PMC11361994

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Excess generation and activation of naturally arising memory-phenotype CD4+ T lymphocytes are inhibited by regulatory T cells in steady state.PMID 39221254Read ↗

Naturally arising memory-phenotype CD4+ T lymphocytes contain an undifferentiated population that can generate TH1, TH17, and Treg cells.Semantic proximity Read ↗

Homeostasis and immunological function of self-driven memory-phenotype CD4+ T lymphocytes.Semantic proximity Read ↗

Bystander memory-phenotype conventional CD4 <sup>+</sup> T cells exacerbating autoimmune neuroinflammationSemantic proximity Read ↗

Memory-Phenotype CD4+ T Lymphocytes: A Double-Edged Sword in Immune Responses.Semantic proximity Read ↗

New insights on T-cell self-tolerance.Semantic proximity Read ↗

Memory-phenotype CD4+ T cells: a naturally arising T lymphocyte population possessing innate immune function.Semantic proximity Read ↗

The endogenous repertoire harbors self-reactive CD4+ T cell clones that adopt a follicular helper T cell-like phenotype at steady state.Semantic proximity Read ↗

Steady-state memory-phenotype conventional CD4+ T cells exacerbate autoimmune neuroinflammation in a bystander manner via the Bhlhe40/GM-CSF axis.Semantic proximity Read ↗

Steady-state memory-phenotype conventional CD4+ T cells exacerbating autoimmune neuroinflammation in bystander manner via Bhlhe40/GM-CSF axisSemantic proximity Read ↗

Striking a Balance—Cellular and Molecular Drivers of Memory T Cell Development and Responses to Chronic StimulationSemantic proximity Read ↗

CD8+ Foxp3+ T cells share developmental and phenotypic features with classical CD4+ Foxp3+ regulatory T cells but lack potent suppressive activity.Semantic proximity Read ↗

Control of autoimmunity by naturally arising regulatory CD4+ T cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.