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Rapid detection of diagnostic targets using isothermal amplification and HyBeacon probes--a homogenous system for sequence-specific detection.

Molecular and cellular probes - 1 Apr 2015

Howard Rebecca L, French David J, Richardson James A, O'Neill Colette E, Andreou Michael P, Brown Tom, Clark Duncan, Clarke Ian N, Holloway John W, Marsh Peter, Debenham Paul G

Abstract excerpt

Isothermal amplification is a rapid, simple alternative to PCR, with amplification commonly detected using fluorescently labelled oligonucleotide probes, intercalating dyes or increased turbidity as a result of magnesium pyrophosphate generation. SNP identification is possible but requires either allele-specific primers or multiple dye-labelled probes, but further downstream processing is often required for...

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PMID: 25542839
DOI: 10.1016/j.mcp.2014.12.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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