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Development of HyBeacon® probes for specific mRNA detection using body fluids as a model system.

Molecular and cellular probes - 1 Apr 2018

Stafford-Allen Beccy, Dawnay Nick, Hanson Erin K, Ball Glyn, Gupta Ambika, Blackman Stephen, French David J, Duxbury Nicola, Ballantyne Jack, Wells Simon

Abstract excerpt

HyBeacons are linear oligonucleotides which incorporate fluorescent dyes covalently linked to internal nucleotides. They have previously been used with PCR and isothermal amplification to interrogate SNPs and STRs in fields as diverse as clinical diagnostics, food authentication, and forensic DNA profiling. This work explores their use for the identification of expressed gene sequences through mRNA profiling. The...

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PMID: 29175285
DOI: 10.1016/j.mcp.2017.11.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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