Article
An isothermal method for whole genome amplification of fresh and degraded DNA for comparative genomic hybridization, genotyping and mutation detection.
DNA research : an international journal for rapid publication of reports on genes and genomes - 30 Apr 2006
Lee Cheryl I P, Leong Siew Hong, Png Adrian E H, Choo Keng Wah, Syn Christopher, Lim Dennis T H, Law Hai Yang, Kon Oi Lian
Abstract excerpt
Molecular genotyping has important biomedical and forensic applications. However, limiting amounts of human biological material often yield genomic DNA (gDNA) in insufficient quantity and of poor quality for a reliable analysis. This motivated the development of an efficient whole genome amplification method with quantitatively unbiased representation usable on fresh and degraded gDNA. Amplification of fresh...
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