Article
TP53 Arg 72Pro and MDM2 SNP309 polymorphisms and colorectal cancer risk: a west Algerian population study.
Pathology oncology research : POR - 1 Jul 2015
Abderrahmane Rym, Louhibi Lotfi, Moghtit Fatima Zohra, Boubekeur Amina, Benseddik Khedidja, Boudjema Abdellah, Benrrahal Fouzia, Aberkane Meriem, Fodil Mostefa, Saidi-Mehtar Nadhira
Abstract excerpt
The tumor suppressor gene TP53 and its regulator MDM2 are both key players involved in multiple pathways including apoptosis, cellular transcriptional control and cell cycle regulation. Common germline polymorphisms in these genes may affect colorectal cancer (CRC) susceptibility. An arginine-to-proline substitution at codon 72 in the TP53 gene is reported to decrease apoptotic potential, while a...
Topics
- Algeria
- Case-Control Studies
- Colon
- Colorectal Neoplasms
- Female
- Follow-Up Studies
- Genetic Predisposition to Disease
- Humans
- Male
- Neoplasm Staging