Article
Impact of MDM2 polymorphism: increased risk of developing colorectal cancer and a poor prognosis in the Tunisian population.
European journal of gastroenterology & hepatology - 1 Mar 2012
Chaar Ines, Arfaoui Toumi Amira, El Amine El Hadj Olfa, Mahmoud Lilia Ben, Khiari Mariem, Sammoud Soraya, Lounis Amine, Amara Semeh, Gharbi Lassad, Hmida Abdelmajid Ben, Mzabi Sabeh, Bouraoui Saadia
Abstract excerpt
INTRODUCTION: MDM2 was originally identified as an oncoprotein that binds to p53 and inhibits p53-mediated transactivation. Scientists have described functional single-nucleotide polymorphisms (SNP) in the MDM2 gene. They showed that the genotype of SNP 309 induces an increase in the level of MDM2 protein, which causes attenuation of the p53 pathway. In this study, we sought to investigate whether this...
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