Article
Polymorphisms of p53 codon 72 and MDM2 promoter 309 and the risk of endometrial cancer.
Human cell - 1 Nov 2009
Nunobiki Osamu, Ueda Masatsugu, Yamamoto Michiko, Toji Eisaku, Sato Naomi, Izuma Shinji, Okamoto Yoshiaki, Torii Kiyo, Noda Sadamu
Abstract excerpt
Genetic polymorphisms of p53 and its negative regulator murine double minute 2 homolog (MDM2) have been shown to be closely associated with tumorigenesis in a variety of human cancers. In the present study, single nucleotide polymorphism (SNP) at p53 codon 72 and MDM2 promoter 309 was examined for germline DNA samples from 102 endometrial cancer cases and 95 controls using polymerase chain reaction-based fragment...
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