Evaluation of the p53 Arg72Pro polymorphism and its association with cancer risk: a HuGE review and meta-analysis.

doi:10.1017/S0016672315000075

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Article

Evaluation of the p53 Arg72Pro polymorphism and its association with cancer risk: a HuGE review and meta-analysis.

Genetics research - 17 Apr 2015

Khan Mohammad Haroon, Khalil Aftab, Rashid Hamid

Abstract excerpt

Codon 72 is a hotspot of polymorphisms in the TP53 gene, which encodes a hub protein in the protein-protein interaction network of p53. It is thus a central player in the apoptotic pathway, preventing cancer. A large number of articles have been published exploring its association with an increased susceptibility to most common cancers. However, these studies have produced inconclusive results, which may be due...

Topics

Asian People
Case-Control Studies
Genetic Predisposition to Disease
Humans
Neoplasms
Odds Ratio
Polymorphism, Single Nucleotide
Risk Factors
Tumor Suppressor Protein p53
White People

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Identifiers

PMID: 25882871
DOI: 10.1017/S0016672315000075
PMCID: PMC6863642

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