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Article

ShcA regulates thymocyte proliferation through specific transcription factors and a c-Abl-dependent signaling axis.

Molecular and cellular biology - 1 Apr 2015

Trampont Paul C, Zhang Li, Giles Amber J, Walk Scott F, Gu Jing J, Pendergast Ann Marie, Ravichandran Kodi S

Abstract excerpt

Signaling via the pre-T-cell receptor (pre-TCR), along with associated signals from Notch and chemokine receptors, regulates the β-selection checkpoint that operates on CD4(-) CD8(-) doubly negative (DN) thymocytes. Since many hematopoietic malignancies arise at the immature developmental stages of lymphocytes, understanding the signal integration and how specific signaling molecules and distal transcription...

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Topics

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Share to Early Growth Response Protein 1
Share to Lymphocyte Specific Protein Tyrosine Kinase p56(lck)

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proto-Oncogene Proteins c-abl

Share to Proto-Oncogene Proteins c-myc

Share to Receptors, Antigen, T-Cell

Share to Shc Signaling Adaptor Proteins

Share to Src Homology 2 Domain-Containing, Transforming Protein 1

Share to Thymocytes

Source

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Identifiers

PMID: 25691660
DOI: 10.1128/MCB.01084-14
PMCID: PMC4372706

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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