Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fluoroquinolone Resistance Does Not Impose a Cost on the Fitness of Clostridium difficile In Vitro

23 Dec 2014

Abstract excerpt

Point mutations conferring resistance to fluoroquinolones were introduced in the gyr genes of the reference strain Clostridium difficile 630. Only mutants with the substitution Thr-82→Ile in GyrA, which characterizes the hypervirulent epidemic clone III/027/NAP1, were resistant to all fluoroquinolones tested. The absence of a fitness cost in vitro for the most frequent mutations detected in resistant clinical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimicrobial Resistance in Staphylococcus
Share to Clostridium difficile and Clostridium perfringens research
Share to Helicobacter pylori-related gastroenterology studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25534738
DOI: 10.1128/aac.04503-14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fluoroquinolone Resistance Does Not Impose a Cost on the Fitness of Clostridium difficile In VitroPMID 25534738Read ↗

Rifamycin Resistance in Clostridium difficile Is Generally Associated with a Low Fitness Burden.Semantic proximity Read ↗

Mutations in the gyrA gene of a highly fluoroquinolone-resistant clinical isolate of Escherichia coli.Semantic proximity Read ↗

Fitness cost of fluoroquinolone resistance in Salmonella enterica serovar Typhimurium.Semantic proximity Read ↗

Molecular analysis of the gyrA and gyrB quinolone resistance-determining regions of fluoroquinolone-resistant Clostridium difficile mutants selected in vitro.Semantic proximity Read ↗

gyrA and gyrB mutations are implicated in cross-resistance to Ciprofloxacin and moxifloxacin in Clostridium difficile.Semantic proximity Read ↗

Effects of low-level ciprofloxacin challenge in the in vitro development of ciprofloxacin resistance in Campylobacter jejuni.Semantic proximity Read ↗

Varying fitness cost associated with resistance to fluoroquinolones governs clonal dynamic of methicillin-resistant Staphylococcus aureus.Semantic proximity Read ↗

Interplay between plasmid-mediated and chromosomal-mediated fluoroquinolone resistance and bacterial fitness in Escherichia coli.Semantic proximity Read ↗

Fitness costs and stability of a high-level ciprofloxacin resistance phenotype in Salmonella enterica serotype enteritidis: reduced infectivity associated with decreased expression of Salmonella pathogenicity island 1 genes.Semantic proximity Read ↗

Evolutionary barriers to quinolone resistance in Streptococcus pneumoniae.Semantic proximity Read ↗

Characterization of fluoroquinolone-resistant mutants of escherichia coli selected in vitro.Semantic proximity Read ↗

Biological cost of rifampin resistance from the perspective of Staphylococcus aureus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.