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Article

Rifamycin Resistance in Clostridium difficile Is Generally Associated with a Low Fitness Burden.

Antimicrobial agents and chemotherapy - 1 Sept 2016

Dang Uyen T, Zamora Idalia, Hevener Kirk E, Adhikari Sudip, Wu Xiaoqian, Hurdle Julian G

Abstract excerpt

We characterized clinically occurring and novel mutations in the β subunit of RNA polymerase in Clostridium difficile (CdRpoB), conferring rifamycin (including rifaximin) resistance. The Arg505Lys substitution did not impose an in vitro fitness cost, which may be one reason for its dominance among rifamycin-resistant clinical isolates. These observations were supported through the structural modeling of CdRpoB....

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Identifiers

PMID: 27381389
DOI: 10.1128/AAC.01137-16
PMCID: PMC4997883

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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