Characterization of fluoroquinolone-resistant mutants of escherichia coli selected in vitro.

doi:10.1128/AAC.38.6.1284

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Article

Characterization of fluoroquinolone-resistant mutants of escherichia coli selected in vitro.

Antimicrobial agents and chemotherapy - 1 Jun 1994

Heisig P, Tschorny R

Abstract excerpt

Wild-type mutants highly resistant to fluoroquinolones were selected in vitro from a quinolone-susceptible Escherichia coli isolate by stepwise exposure to increasing concentrations of nalidixic acid and ciprofloxacin (CIP) either in liquid medium or on solid medium. Mutant R17 was selected by se...

Topics

Amino Acid Sequence
Bacterial Outer Membrane Proteins
Base Sequence
Ciprofloxacin
DNA Topoisomerases, Type II
Drug Resistance, Microbial
Escherichia coli
Microbial Sensitivity Tests
Molecular Sequence Data
Mutation

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