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Article

Biological cost of rifampin resistance from the perspective of Staphylococcus aureus.

Antimicrobial agents and chemotherapy - 1 Nov 2002

Wichelhaus Thomas A, Böddinghaus Boris, Besier Silke, Schäfer Volker, Brade Volker, Ludwig Albrecht

Abstract excerpt

Resistance determinants that interfere with normal physiological processes in the bacterial cell usually cause a reduction in biological fitness. Fitness assays revealed that 17 of 18 in vitro-selected chromosomal mutations within the rpoB gene accounting for rifampin resistance in Staphylococcus...

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Share to Amino Acid Sequence
Share to Amino Acid Substitution
Share to Antibiotics, Antitubercular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Directed RNA Polymerases

Share to Drug Resistance, Bacterial

Share to Electrophoresis, Gel, Pulsed-Field

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Source

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Identifiers

PMID: 12384339
DOI: 10.1128/AAC.46.11.3381-3385.2002
PMCID: PMC128759

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12384339-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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