Article
Mutations in the gyrA gene of a highly fluoroquinolone-resistant clinical isolate of Escherichia coli.
Antimicrobial agents and chemotherapy - 1 Apr 1993
Heisig P, Schedletzky H, Falkenstein-Paul H
Abstract excerpt
We have determined the DNA sequence of the gyrA gene of the fluoroquinolone-resistant Escherichia coli isolate 205096 (MIC of ciprofloxacin, 128 micrograms/ml), which was recently demonstrated to be a gyrA mutant (P. Heisig and B. Wiedemann, Antimicrob. Agents Chemother. 35:2031-2036, 1991). Comp...
Topics
- Anti-Infective Agents
- Base Sequence
- DNA Topoisomerases, Type II
- DNA, Superhelical
- Escherichia coli
- Escherichia coli Infections
- Fluoroquinolones
- Gene Amplification
- Gene Expression Regulation, Bacterial
- Genes, Bacterial
- Microbial Sensitivity Tests
- Molecular Sequence Data
- Mutation
- Plasmids
- Transfection