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Mutations in the gyrA gene of a highly fluoroquinolone-resistant clinical isolate of Escherichia coli.

Antimicrobial agents and chemotherapy - 1 Apr 1993

Heisig P, Schedletzky H, Falkenstein-Paul H

Abstract excerpt

We have determined the DNA sequence of the gyrA gene of the fluoroquinolone-resistant Escherichia coli isolate 205096 (MIC of ciprofloxacin, 128 micrograms/ml), which was recently demonstrated to be a gyrA mutant (P. Heisig and B. Wiedemann, Antimicrob. Agents Chemother. 35:2031-2036, 1991). Compared with the gyrA+ gene of E. coli K-12, 55 nucleotide changes were found. Three of these resulted in amino acid...

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Identifiers

PMID: 8388197
DOI: 10.1128/AAC.37.4.696
PMCID: PMC187737

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