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Article

Differential effects of light and feeding on circadian organization of peripheral clocks in a forebrain Bmal1 mutant.

eLife - 19 Dec 2014

Izumo Mariko, Pejchal Martina, Schook Andrew C, Lange Ryan P, Walisser Jacqueline A, Sato Takashi R, Wang Xiaozhong, Bradfield Christopher A, Takahashi Joseph S

Abstract excerpt

In order to assess the contribution of a central clock in the hypothalamic suprachiasmatic nucleus (SCN) to circadian behavior and the organization of peripheral clocks, we generated forebrain/SCN-specific Bmal1 knockout mice by using floxed Bmal1 and pan-neuronal Cre lines. The forebrain knockout mice showed >90% deletion of BMAL1 in the SCN and exhibited an immediate and complete loss of circadian behavior in...

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Source

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Identifiers

PMID: 25525750
DOI: 10.7554/eLife.04617
PMCID: PMC4298698

Genes

BMAL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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