Article
A clock shock: mouse CLOCK is not required for circadian oscillator function.
Neuron - 4 May 2006
Debruyne Jason P, Noton Elizabeth, Lambert Christopher M, Maywood Elizabeth S, Weaver David R, Reppert Steven M
Abstract excerpt
The circadian clock mechanism in the mouse is composed of interlocking transcriptional feedback loops. Two transcription factors, CLOCK and BMAL1, are believed to be essential components of the circadian clock. We have used the Cre-LoxP system to generate whole-animal knockouts of CLOCK and evaluated the resultant circadian phenotypes. Surprisingly, CLOCK-deficient mice continue to express robust circadian...
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