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Article

A Novel Bmal1 Mutant Mouse Reveals Essential Roles of the C-Terminal Domain on Circadian Rhythms.

PloS one - 1 Jan 2015

Park Noheon, Kim Hee-Dae, Cheon Solmi, Row Hansang, Lee Jiyeon, Han Dong-Hee, Cho Sehyung, Kim Kyungjin

Abstract excerpt

The mammalian circadian clock is an endogenous biological timer comprised of transcriptional/translational feedback loops of clock genes. Bmal1 encodes an indispensable transcription factor for the generation of circadian rhythms. Here, we report a new circadian mutant mouse from gene-trapped embryonic stem cells harboring a C-terminus truncated Bmal1 (Bmal1GTΔC) allele. The homozygous mutant (Bmal1GTΔC/GTΔC)...

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Identifiers

PMID: 26394143
DOI: 10.1371/journal.pone.0138661
PMCID: PMC4578957

Genes

BMAL1
CLOCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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