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Metabolic Profile and Lipid Metabolism Phenotype in Mice with Conditional Deletion of Hepatic BMAL1.

International journal of molecular sciences - 31 May 2024

Gu Weijia, Li Ting, Huang Yuxin, Wang Ruiqing, Zhang Lu, Chen Rucheng, Li Ran, Liu Cuiqing

Abstract excerpt

The disruption of circadian rhythms (CRs) has been linked to metabolic disorders, yet the role of hepatic BMAL1, a key circadian regulator, in the whole-body metabolism and the associated lipid metabolic phenotype in the liver remains unclear. Bmal1 floxed (Bmal1f/f) and hepatocyte-specific Bmal1 knockout (Bmal1hep-/-) C57BL/6J mice underwent a regular feeding regimen. Hepatic CR, lipid content, mitochondrial...

Topics

Animals
ARNTL Transcription Factors
Lipid Metabolism
Mice
Liver
Circadian Rhythm
Mice, Knockout
Mice, Inbred C57BL
Hepatocytes
Phenotype
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Metabolome

Gene Deletion

Lipogenesis

Source

Open in PubMed Open full text

Identifiers

PMID: 38892255
DOI: 10.3390/ijms25116070
PMCID: PMC11172555

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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