Article
Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival.
Science translational medicine - 3 Feb 2016
Yang Guangrui, Chen Lihong, Grant Gregory R, Paschos Georgios, Song Wen-Liang, Musiek Erik S, Lee Vivian, McLoughlin Sarah C, Grosser Tilo, Cotsarelis George, FitzGerald Garret A
Abstract excerpt
The absence of Bmal1, a core clock gene, results in a loss of circadian rhythms, an acceleration of aging, and a shortened life span in mice. To address the importance of circadian rhythms in the aging process, we generated conditional Bmal1 knockout mice that lacked the BMAL1 protein during adult life and found that wild-type circadian variations in wheel-running activity, heart rate, and blood pressure were...
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