Article
Impairment of peripheral circadian clocks precedes metabolic abnormalities in ob/ob mice.
Endocrinology - 1 Apr 2011
Ando Hitoshi, Kumazaki Masafumi, Motosugi Yuya, Ushijima Kentarou, Maekawa Tomohiro, Ishikawa Eiko, Fujimura Akio
Abstract excerpt
Recent studies have demonstrated relationships between the dysfunction of circadian clocks and the development of metabolic abnormalities, but the chicken-and-egg question remains unresolved. To address this issue, we investigated the cause-effect relationship in obese, diabetic ob/ob mice. Compared with control C57BL/6J mice, the daily mRNA expression profiles of the clock and clock-controlled genes Clock,...
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