Article

Mice with humanized livers reveal the involvement of hepatocyte circadian clocks in rhythmic behavior and physiology

2022-09-12

Abstract excerpt

<h4>ABSTRACT</h4> The circadian clock is an evolutionarily acquired gene network that synchronizes physiological processes to adapt homeostasis to the succession of day and night. While most mammalian cells have a circadian clock, their synchronization at the body-level depends on a central pacemaker located in the suprachiasmatic nuclei of the hypothalamus that integrates light signals. However, peripheral organ...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 063e244b-af3b-5ce4-a69d-76899cc649bb
DOI: 10.1101/2022.09.08.506890

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mice with humanized livers reveal the involvement of hepatocyte circadian clocks in rhythmic behavior and physiologyDOI 10.1101/2022.09.08.506890Read

Mice with humanized livers reveal the role of hepatocyte clocks in rhythmic behaviorSemantic proximity Read

Circadian Regulation of Gene Expression and Metabolism in the LiverSemantic proximity Read

Changes in hepatic circadian genes and liver function caused by sleep deprivationSemantic proximity Read

Daily Expression of mRNAs for the Mammalian Clock Genes Per2 and Clock in Mouse Suprachiasmatic Nuclei and Liver and Human Peripheral Blood Mononuclear CellsSemantic proximity Read

Hepatocyte Circadian Clocks Control Cholesterol Metabolism and Protect From Metabolic Dysfunction-Associated Steatohepatitis (MASH)Semantic proximity Read

Circadian Rhythms, Metabolism, and Chrononutrition in Rodents and Humans.Semantic proximity Read

Molecular components of the mammalian circadian clock.Semantic proximity Read

Circadian Clock and Liver CancerSemantic proximity Read

The liver-clock coordinates rhythmicity of peripheral tissues in response to feeding.Semantic proximity Read

A molecular perspective of human circadian rhythm disorders.Semantic proximity Read

The hepatocyte insulin receptor is required to program rhythmic gene expression and the liver clockSemantic proximity Read

The liver clock tunes transcriptional rhythms in skeletal muscle to regulate mitochondrial functionSemantic proximity Read