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Article

Targeting the effector domain of the myristoylated alanine rich C-kinase substrate enhances lung cancer radiation sensitivity.

International journal of oncology - 1 Mar 2015

Rohrbach Timothy D, Jarboe John S, Anderson Joshua C, Trummell Hoa Q, Hicks Patricia H, Weaver Alice N, Yang Eddy S, Oster Robert A, Deshane Jessy S, Steele Chad, Siegal Gene P, Bonner James A, Willey Christopher D

Abstract excerpt

Lung cancer is the leading cause of cancer related deaths. Common molecular drivers of lung cancer are mutations in receptor tyrosine kinases (RTKs) leading to activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pro-growth, pro-survival signaling pathways. Myristoylated alanine rich C-kina...

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Source

Identifiers

PMID: 25524703
DOI: 10.3892/ijo.2014.2799

Genes

MARCKS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25524703-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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