Article
Chk1 phosphorylation of Metnase enhances DNA repair but inhibits replication fork restart.
Oncogene - 20 Sept 2012
Hromas R, Williamson E A, Fnu S, Lee Y-J, Park S-J, Beck B D, You J-S, Leitao A, Laitao A, Nickoloff J A, Lee S-H
Abstract excerpt
Chk1 both arrests replication forks and enhances repair of DNA damage by phosphorylating downstream effectors. Although there has been a concerted effort to identify effectors of Chk1 activity, underlying mechanisms of effector action are still being identified. Metnase (also called SETMAR) is a SET and transposase domain protein that promotes both DNA double-strand break (DSB) repair and restart of stalled...
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