Article

Radiotherapy drives lung metastasis in PDAC via a RhoGTPase signaling shift towards MRCK-dependency

2025-09-14

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with an extremely poor prognosis, partly owing to its highly metastatic nature. Although radiotherapy is an effective and potentially curative treatment modality, research over the last few decades has indicated that it may induce a more metastatic phenotype in surviving cancer cells. We demonstrate for the first time that clinically relevant doses of...

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Literature Corpus work: e056086b-497d-5fb0-98d7-991cef1fb331
DOI: 10.1101/2025.09.09.673965

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