Article
SCAMP3 is a mutant EGFR phosphorylation target and a tumor suppressor in lung adenocarcinoma.
Oncogene - 1 May 2021
Venugopalan Abhilash, Lynberg Matthew, Cultraro Constance M, Nguyen Khoa Dang P, Zhang Xu, Waris Maryam, Dayal Noelle, Abebe Asebot, Maity Tapan K, Guha Udayan
Abstract excerpt
Mutations in the epidermal growth factor receptor (EGFR) tyrosine kinase domain constitutively activate EGFR resulting in lung tumorigenesis. Activated EGFR modulates downstream signaling by altering phosphorylation-driven interactions that promote growth and survival. Secretory carrier membrane proteins (SCAMPs) are a family of transmembrane proteins that regulate recycling of receptor proteins, including EGFR....
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