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Article

PKCα as a signaling gatekeeper upstream of mTORC1 in mEGFR NSCLC.

Advances in biological regulation - 1 Jan 2026

Sadeghi Mojtaba, Chiappone Sam B, Salama Mohamed F, Hannun Yusuf A

Abstract excerpt

Despite decades of research since phorbol esters first linked protein kinase C (PKC) to tumor promotion, the biological role of this family of kinases in cancer has remained ambiguous because of isozyme-specific functions and tissue-type-dependent effects. Here, we delineate critical roles for PKC in lung cancer. We previously showed that sustained activation of PKCβII activates mTOR, an effect evident in lung...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41188146
DOI: 10.1016/j.jbior.2025.101122

Genes

EGFR
PRKCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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