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Article

Threonine 2609 phosphorylation of the DNA-dependent protein kinase is a critical prerequisite for epidermal growth factor receptor-mediated radiation resistance.

Molecular cancer research : MCR - 1 Oct 2012

Javvadi Prashanthi, Makino Haruhiko, Das Amit K, Lin Yu-Fen, Chen David J, Chen Benjamin P, Nirodi Chaitanya S

Abstract excerpt

The EGF receptor (EGFR) contributes to tumor radioresistance, in part, through interactions with the catalytic subunit of DNA-dependent protein kinase (DNA-PKc), a key enzyme in the nonhomologous end joining DNA repair pathway. We previously showed that EGFR-DNA-PKcs interactions are significantly compromised in the context of activating mutations in EGFR in non-small cell lung carcinoma (NSCLC) and human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22923485
DOI: 10.1158/1541-7786.MCR-12-0482-T
PMCID: PMC3475795

Genes

EGFR
ATM
EGF

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Threonine 2609 phosphorylation of the DNA-dependent protein kinase is a critical prerequisite for epidermal growth factor receptor-mediated radiation resistance.PMID 22923485Read ↗

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