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Article

Transmembrane protein 2 (Tmem2) is required to regionally restrict atrioventricular canal boundary and endocardial cushion development.

Development (Cambridge, England) - 1 Oct 2011

Smith Kelly A, Lagendijk Anne K, Courtney Andrew D, Chen Huijun, Paterson Scott, Hogan Benjamin M, Wicking Carol, Bakkers Jeroen

Abstract excerpt

The atrioventricular canal (AVC) physically separates the atrial and ventricular chambers of the heart and plays a crucial role in the development of the valves and septa. Defects in AVC development result in aberrant heart morphogenesis and are a significant cause of congenital heart malformations. We have used a forward genetic screen in zebrafish to identify novel regulators of cardiac morphogenesis. We...

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PMID: 21896629
DOI: 10.1242/dev.065375

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